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Image Search Results
Journal: EMBO Reports
Article Title: A novel long intergenic noncoding RNA indispensable for the cleavage of mouse two‐cell embryos
doi: 10.15252/embr.201642051
Figure Lengend Snippet: In normal two‐cell mouse embryos, LincGET works as a transcription factor, mediating the cis‐regulatory activity of GLKLTRs, and an inhibitor of exon skipping, partially through decreasing hnRNP U, FUBP1, and ILF2 protein levels (up). However, when LincGET is depleted, disordered transcription and disordered RNA splicing would result in disordered ZGA, MAPK signaling inhibition, and exon skipping of some M‐phase‐associated genes, including Cdk1, leading to G2/M block (down).
Article Snippet:
Techniques: Activity Assay, Inhibition, Blocking Assay